TraMADol hydrochloride exposes sufferers along with other customers to the threats of opioid habit, abuse, and misuse, which can lead to overdose and death.The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors on levels of tramadol and M1 from tramadol hydrochloride tablets are complex.